Is this a joke post? How do you plug in a riser in the wrong direction? Do you have a pic? Are you referring to the part that goes in the 1x slot?
It's very possible, grab a motherboard you aren't using and a bad riser connector to give a try you will see that it's 💯 possible, I killed a Nvidia card this way some time ago and it thus affects me because I couldn't get my ROI faster