NOT MUCH DIFFERENCE
In hash rates.
But overhead in power - extra GPU, Memory and so on. So go for one PC.
Some times you would be right other times wrong.
Myself If i had 4 good cards rich now I think I would want 2 machines that could expand to 5 or 6 cards.
I wouldn't want 1 machine or 4 machines
but 2 is better than one in a choice point of 1 or 2.
Reason is if 1 dies you can trouble shoot really fast.
1 machine if it dies means very hard trouble shooting.