Personally, it is possible but the experience can be similar to driving a car for the first time without knowing the use of pedals.

In trading, knowledge about the fundamental and technical analysis of a cryptocurrency are essential in order to mitigate the risk of losing your money. By those indicators, you would be able speculate safely the trend of its price either it increases/decreases. Of course, it is possible to trade without knowing those indicators but you increase the risk of you losing money by a significant amount.