I think it is very interesting to sell about 1-10% when you reach 1000-10000% profits.
This amount of gain does not happen that often and it only does on very low cap altcoins which is very difficult to know what could increase that much in the future. If I would experience that kind of gain I would probably sell all that coin at 1000% gain.
You say that because you are not a holder

I have more than 1000% on bitcoin (considering my local fiat currency). But since 2017 , when it was less than 5K, bitcoin has done more than 1000%. ANd 4 years is not a very long investment...
And yes, I am doing this strategy, selling from 1-10% of my stash (depending on how long will this bull run go, I am selling a few every month since a few months already.)