You should try to avoid such coins for long term hold. Fro short term day trade is totally fine but for long term you will get burned. Right now we are in bull market and volume of all coins is x100. So when bear market start if a coin have $100k daily trading volume it will have $1k when bear market start. And you will simply not be able to sell them at all.
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There will have always low safety of your portfolio and higher profit. We invested in the high volume altcoins because of volume of selling time. You can't invest high portfolio, those options are for low investor.