In my opinion, Real Madrid lost the chances of the La Liga title in the match with Sevilla, and Barcelona lost to Granada. I don't think Atletico Madrid will lose points against Osasuna and Valladolid, although Valladolid needs points to stay in La Liga next season.
Osasuna and Valladolid are not strong teams. If we look at Atletico Madrid's previous head-to-head performances against Osasuna, we can see how much stronger Atletico Madrid is than Osasuna. Osasuna have not won any of their last five matches against Atletico. And they conceded 16 goals. And against Atletico they were able to score only 1 goal. It seems that Atletico will win easily in today's match as well.