You're about Ron DeSantis to be the best candidate for the next POTUS elections but I still don't see him as powerful contender for Biden and for the Trumps, if the Republican like themselves they wont let any of them run for the next POTUS election due the practise and the drama created by Donald Trump.
It is too early to say whether DeSantis will get the nomination or not. It can't be predicted so early. Back in 2015, hardly anyone thought that Donald Trump would manage to get the Republican nomination. During the early months, Jeb Bush and Ted Cruz were among the leading contenders for this post, along with John Kasich and Marco Rubio. Chris Christie was considered one of the favorites until 2014, when he got embroiled in the "Bridgegate" controversy. If you check the opinion polls, then Ron DeSantis and Mike Pence are leading the polls right now. But it may be too early to reach a conclusion here.
Biden just started his office late last year and it’s too early for this kind of prediction since we don’t know who will represent both parties and seriously, I’m still looking for the early projects of Biden and what he has done for over a months now. Mike Pence might be one of the option, we’ll see about this in the next 3 years, too early for this.