A lot of posts in this thread, and in posts in other, similar threads talk about the required fee to get a single transaction confirmed, but this fee rate would probably not be appropriate if you need 50, 100, or more transactions confirmed in nearly every block, as many larger bitcoin businesses may need.
If you are one entity and need that many transactions, it may make more sense to combine the transactions into one... also called batching. Don't do 50 or 100 separate single transactions, do 1 transaction with 50 to 100 inputs/outputs as needed, wait a few minutes to accumulate a bunch, ask the user if they are willing to wait to pay a lower fee.