It goes without saying if bitcoin were to become worth $1M, or even $100k, then it might be very tempting to cash that amount out and install a much small amount in its place.

With BTC 10 I'd probably go the other way and open 1,000 channels worth BTC 0.001 each.  That would enable me to  have a much wider spread of nodes / regional access than just sending coins backwards and forwards to just one other node.