What do you want to achieve?

If you create a 2FA wallet, you will be asked to enter the 2FA code whenever spending bitcoin.
This will make your fund secure in the case your device is stolen or someone manage to access your wallet file.

Note that even if your wallet is 2FA, your seed phrase is enough for spending your bitcoin.

Also note that, in 2 2FA wallet, you will have to pay an additional fee to trusted coin (Electrum 2FA wallet provider).