For me, that had to be Ripple. I traded for 100%+ thrice and still holding a position at $0.40.
My next coins are:
1) Ripple
2) ADA
3) Bitcoin
4) Ethereum
What's yours?
For me the biggest profit was when I invested in one Defi-project and in its native token. The name of it was Iron Finance. A lot of people lost there, but when some people are losing, others are earning. It is a brutal market law. I bought this token when it cost 8$ and then it rose up to 60$. Some traders will scoff at my small earnings, as it increased only by 7 times, but anyway, I hope that it was only the start.