Spurs can be unpredictable sometimes and had they been managed by Mourinho I would say a win would have been possible but not this one, and besides Manchester City has been a class of their own during the friendlies and I don't see them dropping points In their first game of the competition.
My prediction: Tottenham 0-3 Manchester City, unless the home fans have an impact because fans are back we might have a different result.
This match won't be an easy winning for Manchester City. Tottenham will definitely give them a tough time. But my prediction is both team to score. Although, Manchester City is one of the strongest club in the EPL, and with an experienced Coach, they will try and win the match. Tottenham might surprise us by winning, City won them in the EFL final last season. Let's see how the match will eventually end.