There will be restaurants and flights that only take the unvaxxed as their customers. Capitalism is awesome.
Logically speaking, no business will cater a "Unvaxxed Customers ONLY" as there is a huge gap between vaxxed to unvaxxed. If you do this, then there is a tendency that your business will be ruined not unless you overprice the products, or build your business in a unvaxxed concentrated location
