The major factors affecting bitcoin are :
Change in government - it's simply means when another government enter there's will be reduction or addition of some policies.
Political instability - when political system in the country is not stable, everything will get down.
Factors would be;
1. Regulation/ Government decisions towards bitcoin or crypto as a whole.
2. Personal problem by owners with volatility
I dont see anything or other than that when it comes on affecting bitcoin business because volatility and regulation would be the main thing
but its impossible that business owners arent really aware with that.