No, it's not possible to use Atomicdex with hardware wallets, and even if you could do it there is a problem with low low volume and low liquidity.
If you check dexstats.info you will see that total volume for last 24h was only around $51500 or 1.12 BTC, and majority of trades are done just for KMD/TKL trading pair.
That means you can't really use Atomicdex in real life yet, and Bitcoin addresses there are still using only legacy format starting with 1.