They could have certainly won the game even without Ronaldo and Pogba on the pitch, but you have those days where you can't turn your dominance into success.
He is 36 years old and he cant play three times a week for full 90 minutes anymore. Its far more tiring playing in Premier League compared to the other league so yeah Ole's decision is pretty much reasonable but it cost the team full 3 points. The questionable decision was subbing Sancho, he could have subbed in Lingard instead.
They do have the players for it.
We do and it will be the end of Ole's reign if Manchester United cant win EPL or either Champions Legue this season