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IMO, he should continue fighting if he wants and just consider Tyson Fury his kryptonite. In boxing, "styles makes fight" so let's just assume that Fury got his numbers. We can't deny that Wilder is one of the feared champions in the heavyweight division and almost all of them have losses so nothing to be ashamed of, it's just one have to lose.
Wilder was picking and choosing fighters and he had confidence in his power despite the fact that he is not a technically great boxer but have immense power in his hands and once he faced Tyson Fury who was not going down with his power punch he was not able to do anything and if Fury continues his usual strength then he will win the trilogy and hopefully we will not hear any further excuses.
Fury had been knockdown once, so he feel the power of Wilder, it's just that Fury is so good at moving around and take note, he also has the power so he can hurt Wilder. As long Wilder cannot connect with clean punches on Fury, I think the same result will be seen, Fury will win via UD or a KO at worst.