Basically, before Napoli against Inter it seemed that Napoli's position was very safe, even though at that time Napoli had to play in the Europa League but the opponent was only Legia which I think it's not a big problem for Napoli. Unlike Inter, at least Inter got a tougher opponent before against Napoli. Yes, Inter have to play against Milan first before against Napoli, the obstacle for Inter is definitely tougher here and with that factor too I'm sure Napoli will be able to take advantage of the situation well.
Napoli won't spend too much attention and player resource for Europa League because to win it, they need to fight and need luck too. In Serie A, they have a very good season so far and they don't want to lose this advantage. Especially Juventus are rebuilding their team with the first season of Max.
The biggest competitors of Napoli in Serie A are AC Milan and Inter Milan and they will try to focus to protect their chance to win Serie A with more pressure from Milans and perhaps Juventus.
Decentralize their player resource to Europa League will be harmful for Napoli. So I don't predict result of this match.
Actually, Napoli has a better chance at winning the league which for me seems like more important than the EUL. Also, they can somewhat qualify for the next round by playing some average players. The coach will play an important role over here. Squad rotation is very important as he would surely not want his main players fatigued before a crucial match in the league. Also, their next EUL match is against Legia so maybe the coach can rotate some players here and there.