Always bad. Im always closing out positions at those days to avoid losses. I dont know exactly why but at Saturday, its always bearish and continuing up to Sunday. Bullish starts on monday giving signs of life and that whole week would be bull given that no fud spreads. So keep out of it. Just do one during weekdays.
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People tends to spend on weekends, I sometimes withdraw some BTC before whenever weekends approaching if I have some plans to buy. I regretted that since I wasnt able to save much BTC before the proce pump. Trading weekends can be done if yoyr a day trader. It can work if some coins dump and a certain time it might increase and get a profit. It is applicable if you want to spend your whole weekend trading.