As I can see the fault now:
2021-11-27T22:36:53Z Opening LevelDB in E:\Bitcoin\blocks\index
2021-11-27T22:36:53Z Fatal LevelDB error: Corruption: 41 missing files; e.g.: E:\Bitcoin\blocks\index/000313.ldb
2021-11-27T22:36:53Z You can use -debug=leveldb to get more complete diagnostic messages
2021-11-27T22:36:53Z Fatal LevelDB error: Corruption: 41 missing files; e.g.: E:\Bitcoin\blocks\index/000313.ldb
2021-11-27T22:36:53Z : Error opening block database.
Please restart with -reindex or -reindex-chainstate to recover.
the best way will be starting bitcoin-qt from the cmd with the suggested -reindex
So you need to press [Start] and inn the [Eingabeaufforderung] you type cmd to get a console
there you cd int your folder where bitcoin-qt is located
now you type: bitcoin-qt.exe -reindex and press enter