Yes, anything can happen, because luck is a factor in the game of poker. An absolute newbie can beat the best poker player in the world in one game or even more. But the more games played, the more obvious the importance of experience and skill, so a weak player, or someone using an outdated strategy, doesn't stand a chance in the long run.
For sure newbies will always lose in bluffing, because newbies does have a weak resolve to fight for their cards, so the only option they have is to fold. But in the long run, as they are making experience, they will also start to make profits using their own strategy against other professional players. Poker is like chess, it's a mind game and the smart one will always win.
The professional players reading the same books, so they play one of the strategies that another professional players know. And noone no how will play newbie. This is his only weapon, except luck. And when newbie get skill he ceases to be a newbie, but becomes play one of the known strategies with more skilled players.