I think must popular and profitable cryptocurrencies in 2021 are Binance Coin, Shina Inu, and Solana followed by the metarverse coins such as Decentraland, Sandbox, and Gala Games. DeFi and Meme coins also has an excellent run where their market capitalization have grown exponentially. In this year 2021 we witness one of the successful years for cryptocurrency where the entire market capitalization went turbo from $400 million to $3 Trillion.