Here are some of the match that I think will be the most interesting in the last 16 of the Champions League 2021/2022 season. For other match, I think the favorite team will easily qualify for the next round although sometimes it can be wrong because this is football.

PSG vs Madrid is one of the toughest in my opinion although I think Madrid fans are very enthusiastic to think that they can qualify easily because PSG is the opponent. I don't agree with some of them who think so because honestly PSG are here to give their best in every game they will play. Winning and losing is common in football but it's about who is the best and who goes through to the next round and I think both team will have an equal chance of that.
My favourite teams to pass this round respectively are PSG, Liverpool and Manchester United. And I bet that most people have the same opinion as mine. Compared to the other draws, Liverpool have an easier job to do against Inter. I don't underestimate Inter, don't get me wrong about it. I just say that both of them are strong teams but Liverpool's game is way ahead of Inter now.