Portuguese players are actually quite good and some of their names can be said to be famous names but their performance in the national team is very different at the club.
they seem to lose momentum and cooperation when playing at the national team level.
talking about their coach actually i see ronaldo more often giving instructions than fernando santos

This case happened to many teams because they faced some difficulty in national teams, even having some very good players with good skills and quality. Portugal has this for some years and on other side Italy never have any issue like this because they are better unit in national team even they are having some bad time for last world cup and now again at a crucial time their team lost momentum, and they are playing qualifier, but they are in better shape then Portugal.
It is the biggest advantage for them in next qualifier Portugal is having some other issues as well as peoples saying Ronaldo is trying to hijack all things in place of his coach which is also having issue, but many things could be handled in better way for mega events.