PSG vs. Real, Villarreal vs. Juve, Atletico vs. ManU are very unpredictable pairs, I'll wait a real rumble there...In each other pairs I can see a clear favorite, excluding, maybe, Benfica vs. Ajax.
The PSG Vs Real Madrid match will be an interesting match. The two teams are in good shape. PSG are leading in the Ligue 1 standings, while Real Madrid on the other hand are also leading in the La Liga standings. Is quite hard to predict who wins, but I think many goals will probably be scored. Atletico Madrid will have a tough match against Manchester United. Atletico Madrid have to play this match carefully to avoid losing, Because Manchester United focus are mainly on their Champion League matches. However, the Round 16 will indeed be very interesting, and I can't wait.