Right now everyone should look for non-Scrypt coins as these are the ones that will do well when the Scrypt ASICs hit. Take a quick read of the article on Scrypt and the impact that ASICs will have, there's a bit of history in it for SHA-256 ASIC impact.

Changing landscape for GPU miners

Scrypt-Jane and Adaptive-N give diminishing returns. There is X11 by Evan Duffield which performs better than Scrypt and uses less energy. Take a look at Hirocoin, it is a thoroughly coded and looks to be the new home for GPU miners. When GPU miners look at the cost of mining and factor it in X11 will be the next choice for them, due to the complexity of X11 it will be ASIC free for a long time even if there is another round of ASICs.

http://www.hirocoin.org/img/hirocoin.pnghttp://www.hirocoin.org/img/x11small.png