Yes, depending on the Fans and the temperature at the radiator 3 fans are enough.
I use server cases so always 1 good 3 fan radiator.
On my 3080s i have got ek waterblocks.

0: Msi NVIDIA RTX 3080 10GB 94.02.42.00.F7 1155/10425 100.06 MH/s 228 W 54℃ / 0%
1: Msi NVIDIA RTX 3080 10GB 94.02.42.00.F7 1155/10425 100.07 MH/s 217 W 54℃ / 0%
2: Msi NVIDIA RTX 3080 10GB 94.02.42.00.F7 1155/10425 100.07 MH/s 222 W 52℃ / 0%
3: Msi NVIDIA RTX 3080 10GB 94.02.42.00.F7 1155/10475 100.59 MH/s 210 W 45℃ / 0%
400.78 MH/s   917 W