harmony could be good investment for 2022 cause since 2019, it keep performing good and because of having network layers as well as protocol, which can serve us secure & scalable blockchain system. but quite hard to say most profitable for 2022. Eth, bnb, matic and lots of altcoins can be added on that list. Or it also possible by any new altcoins that could break most profitable altcoins record
better focus on popular coins for now. we can see that big discounts occur on any coin when the bitcoin price dumps. You can create a portfolio in 2022 starting with bitcoin, ethereum, bnb, matic, ADA, and other popular coins that you believe that when the market recovers, the price of the coins you hold on to could be higher.
personally, right now I'm going to focus on BNB. I'm pretty sure that when the price rebounds, it could be as high as $600. In addition, the price is currently still very affordable. I'm sure many will start investing in BNB for now.