If I had an "extra" house, I could have sold it in 2016 too as I was trying to invest as much as I could (within some strict limits), but selling the house where I live-you have to be a bit more adventurous-like the Taihuttu dude (he sold the house when btc was $900, became a nomad with his whole family).
In any case, selling a live-in house to try to gain a bit of leverage is probably beyond most people. I have seen a couple reports like this, but usually it was a second house of a house that was inherited.
If you have no family depending on you and you do not have a partner I would do this right away. Sell the house for $300k buy a small camper van to live in so I am not homeless and travel the country by setting aside 10k. By the time I have traveled all states I would probably profited by at smallest 1.5x.
280k x 1.5 = 420k
that is the minimum i would think it rises it probably would be 2x
I could move into a house bigger then I have now for 1-2 years of living in a camper van. I would not need a mortgage and if a short time I would have improved my lifestyle forever