Lille and Villareal are not the seeded teams that have so far made it through to the round of 16. So far Villareal are playing well in Laliga and some time ago they also managed to draw with Real Madrid 0-0, I think they can score but not win the match vs Juventus. But things are different for Lille because so far their performance in Ligue 1 has been very unstable. Lille have been unsatisfactory so far as they have won just 9 of their current 25 match in Ligue 1 and I'm sure Chelsea will beat them from today's first leg.
My prediction:
Chelsea vs Lille 4-1
Villareal vs Juventus 1-3
Even though Lille and Villareal are not the top teams, I think the predictions are too many goals. The two teams between Lille and Villareal will definitely focus more on defending by relying on counter attacks and making Chelsea, Juventus will have difficulty scoring 3 more goals. Despite the unstable performance of Lille, Villarreal are a team with a good performance in La Liga and I think the prediction is more correct like this.
Chelsea vs Lille 2-0
Villareal vs Juventus 0-1