Maybe some core players will be rested just to play in the champions league (only 4 days later with the match vs Burnley), so that play in the premier league as just the second player. but of course, that very risk, even against Burnley a club which degradation zone, if they can't get a win, Liverpool can beat them in 1st stand.
I see advantage from Manchester City squad with completed player and not any different quality or skill between regular and not regular player, I see they not looks worry about which one 11 player on domestic league or champion league. Next match on 4th April Manchester City have away match against with Burnley and speculative as easy match for Manchester City get 3 points although have use with not regular player on starting eleven, later Pep Guardiola will focus on quarter final champion league against with Atletico Madrid four days later with regular player.