Why not?
Advertising becomes effective when a person repeatedly sees the same brand advertised.
If the content of the topic, regardless of its size, is content with quality and updated, the advertising presented is always an opportunity to promote the product.
In short, what I think is important is not the size of the topic, but its content.
Well, since you ask me I'll answer you, let's see if you and me, and maybe someone else who can possibly comment can find out how this works, and at the same time we do some free publicity for Jambler.io.
I believe that in this advertising there are two components, SEO and the fact that potential customers see the advertisement and can go to the website being advertised.
For SEO it doesn't matter where the posts are published.
On the other hand, a potential customer is not going to read your comment on page 37 of a quality megathread when it reaches page 40. When it reaches 38, maybe. However, if you are the creator of the megathread, it is very likely that potential customers, especially if they visit the thread for the first time, will read your OP, every time someone comments, because the thread is bumped.
Maybe someone could show me a statistical analysis to the contrary, but if I were an entrepreneur putting advertising on the forum, what I would be looking for above all is people who create threads and publish posts on the first pages. That's where the advertising is going to have the most impact on my potential customers.
Why do you think there are many sections that signature campaigns do not pay for, such as off topic or politics? I don't think it's because of the spam there. If it was because of spam, none of them should pay for posting in Gambling and Bitcoin Discussion which are full of spam. The issue is not about spam, it is about impact on potential customers.
A quality post in off topic is going to have a very low impact on potential customers, much less than one of the same quality published in Bitcoin Discussion or Gambling.
That's what I think, but maybe someone who knows more about how this works will change my mind.