With Real Madrid confirmed as champions and Barcelona looking like they have secured their second spot, it's clear that that the only spot left to fight for is the 4th position which is currently being held by Atlético Madrid who seem to be inconsistent with results delivered, and if they become playful with the last two games they could lose the spot but I don't see this happening.
Mathematically, the second spot could be revoked from Barcelona at any time with 4 games left this season, but in real life, Sevilla and ATM are at their worst time to be able to oust Barca from there.. Actually ATM position is no longer secured imo, it all depends from Betis performance for now.
Looking at the relegation zone, Granada journey in La Liga seems to end soon after being in top 10 for the last 2 seasons.