psy: In what experience I had, the biggest barrier is doing the initial load of the blockchain. It was fairly I/O intensive and wrought havoc with my VPS. I eventually had to give up (as it would have taken several days to finish), and run it instead on my local machine. However, the particular host machine my VPS is on has had a history of high I/O load from other users, so it's possible it might work better elsewhere.