Chrome browser is my preferred choice and I had been using Metamask extension wallet on it without any issue, though I agreed with you that every users has to be very careful with the likely external compromise by hackers via Antivirus and other computer softwares, Sophistication in hacking and phishing has been in a large scale in recent time and this a big challenge for crypto hodlers thus their is the need secure our coins by taking extreme precautions, like unnecessary downloads, clicking of phishing sites, opening unwanted spam emails e.t.c if possible I will use a single PC or laptop for hodling my coins while other ones for my jobs.