I used to mine on 2miners but profit declined so I moved to Ethermine. Default settings are ok for stales,
Ethermine doesn't pay for stale shares. On default intensities there are around 2% stales, this is higher than in the other mining software, but doesn't matter on the 2miners pool.
If you increase the intensity you can get as much as +5% poolside hashrate. The +5% accepted hashrate will probably give you more coins in the pocket..