I remember seeing an article when the big DOGE boom happened a few years ago which was talking about a guy looking to sell his house and accept DOGE (I hope he didn't end up doing it seeing the price of the coin now).. Anyways, that tells me buying (or selling) real estate for crypto is definitely possible. My advice would be if you were really looking to acquire some real estate with Bitcoin then talk to a realtor in your area. Nobody would know better than them and if you're serious, they would try and find a way to make it work since they get a commission.