While I am one of Messi's biggest fans in South American team, I believe the current team will need luck to win the world cup. The last time a South American team won the FIFA World Cup was Brazil. As a result, Argentina's chances are stacked against them. It doesn't matter what, European countries always dominate. Yes, it would be incredible to see Messi or Ronaldo lift the FIFA World Cup trophy in 2022.
I doubt Portugal will reach the final, although I would like to see it. Portugal has the players to get there, it remains to be seen if they will be focused enough for that.
But it would be very nice to see an Argentina vs Portugal final, because they are two teams that have never played against each other.