It will still be protected from spam, because getblocktemplate and similar commands always put transactions from the highest to the lowest fee, so with those settings, free transactions will be included only if there is a room for them. And meanwhile, they could be combined with full-RBF, or they could even increase in fees, so that 500 transactions A->B->C->...->Z paying one satoshi each could be compressed into a single transaction with 500 satoshi fee.