I don't know, even Mike himself said that he "may" lose to Kobe in one on one. Not that because he believes Kobe is a more talented player than Mike, he himself knows that he is better, but he knows that Kobe studied Mike more than anyone ever did, and he knows what Mike does in what situation, he literally memorized everything Mike has ever done and knows his tendencies more than anyone. Sure nobody playing right now would beat Mike, but I believe there is a good case to be made about Kobe.

Also, I am not sure if big guys count, like for example it would be hard for Shaq to guard Mike, but it would be damn impossible for Mike to defend against a peak Shaq as well, but they are so much different in body size, so it could be a bit different calculation there.