If the gambling sites depend on the value of the cryptocurrency then, it has a big impact on gamblers. But, I think that gambling sites use cryptocurrency which is not converted to USD since we all know that market is very volatile it can go up and down.
I think that much more on the personality. Remember that some gamblers used USD of fiat money to bet but others may used crypto to bet in the betting platform. You can't deny the fact that if gamblers itself who will be determining which value that will be used to gamble whether it will peg with fiar or crypto. In this case the site can't be blamed once crypto gamblers loosing their money
Those who are usually use crypto gambling site definitely realize the issue. There are some gamblers prefer to use stable coins and some other gambling on Bitcoin or Altcoins. To avoid the volatility of this cryptocurrency, gamblers must stabilize their assets or gamble with little risk. I think generally gamblers are ignore the normal volatility to continuing gambling with out any interruption.
In general, crypto gamblers who often gamble will ignore the volatility in the market because they find their world in gambling. But crypto gamblers who rarely gamble will think about market volatility and wait for the market to stabilize before depositing their coins on casino sites. But gamblers will know what to do if the market is stable or not and will choose what they feel comfortable with. So it will be up to the individual gambler to solve the volatility issue and act based on what they think is good for them.