Yes, Atletico Madrid has great potential to interfere with Real Madrid's chances of defending the title. My prediction this season is that the La Liga title race will be competitive again, even though many people still favor El Real.
It's still too early to say who can compete with Real Madrid in La Liga. Atlético start the last season also not bad, but then even Barcelona, which had a very difficult season, managed to get ahead them. So far, Real Madrid looks like the favorite for me, and in order not to get too far ahead, let's look at Saturday's match against Celta. I think that it will not be a problem for Real Madrid to beat them for odds 1.7, which is not bad at all.
Everything can still happen, now that the league has just started and it is still very difficult at this time to say which team has the potential to win even though there are only a few clubs as usual to subscribe to but still there must be some problems that cannot be contained as happened to Atletico last season there with a storm of injuries they received that prevented them from developing their form in the middle of the season.