Yes, Atletico Madrid has great potential to interfere with Real Madrid's chances of defending the title. My prediction this season is that the La Liga title race will be competitive again, even though many people still favor El Real.
It's still too early to say who can compete with Real Madrid in La Liga. Atlético start the last season also not bad, but then even Barcelona, which had a very difficult season, managed to get ahead them. So far, Real Madrid looks like the favorite for me, and in order not to get too far ahead, let's look at Saturday's match against Celta. I think that it will not be a problem for Real Madrid to beat them for odds 1.7, which is not bad at all.
Of course it is too early to determine who will take the title from Real madrid. Everything are making good performance at the start of the league it doesn't mean it will gong well like that. Most time some teams starts very well in the beginning but has the league continues things change. Their are some teams that will start badly and may improve middle of the league. Real Madrid are too strong to lose the title.