It seems that the coach factor is no longer important because Mourinho himself in my view has not been very successful in making changes for Roma, although some new players and become key players still have not had a maximum impact on the team's performance. So with this situation I personally still consider that the home team will be able to win the match, or if we consider the situation of the two teams so far this season a draw could happen. But I personally still believe that Inter do have a better chance of winning.
Seem AS Roma still not really successful under Jose Mourinho era although last season with first trophy achievement UEFA Conference League, can't finish on top fourth standing position and loss UEFA Champion League ticket I think enough reason with Jose Mourinho is not special coach nowadays. Could be second chance for Jose Mourinho bring back AS Roma to top standing position although this season have got 2 loss and left not many points different with first standing position Napoli with 4 points.
Need to win on next match against with Inter Milan if want settle top position standing, however AS Roma have bad result against with top team after last match defeating by Atalanta, will Inter Milan become moment for AS Roma recovery and back to winning record or Jose Mourinho always weakness when AS Roma faced with bigger team.