I think it's not safe to interact with any new sellers, you never know how they will handle the transaction and what type of item them will send ( present condition ), I always try to buy from those who have sold few times before and have good reviews from their buyers.
With eBay I would say its pretty safe because your purchase is guaranteed. eBay support always sides with the buyer. I had people buy many GPUs and ASICs and I had to take them back for made up reasons.
Only issue with a new seller is that they might not do the best job of maybe packaging it up or shipping it correctly, or they can take their time going to the post office. However they won't scam you. No point in sellers ripping off buyers on ebay anymore. So if its a great deal, cheaper than most other sellers I would say go for it.