Every wallet can be targeted if you don't use them properly (same goes for hardware, although most of what you have to do with hardware is decide if you initiated the transaction and if it's as you expect - although there are still some issues with smart contract signing afaik).

Trustwallet is about as secure as metamask though and depends more on your computer's security than hardware would. If you are only using it for small amounts then it's safe enough.

If you're storing high values of many tokens it would be safer to have multiple hardware wallets with different wallets/passphrases to ensure you won't get scammed when signing erc20 transactions and similar. If you're working with a few altcoins but they're of lower value, using a mix of trusted wallets is probably the most secure way (and perhaps a hardware wallet for things you're less likely to spend or for coins you need larger amounts of - for fees - like bitcoin or ethereum).