Running a business during the bear market is as difficult as it gets. I am not saying that it will be something that will be profitable, or it has to be a loss, it could be either based on how you manage it. But, the best thing to do would be making sure that even if you are not making a profit, you have enough saved aside to go on and wait until the bull run comes again.
That means you could make insane returns during the bull run, and if you save that aside, then you could maybe wait for a year or two until you make that type of profit again. Their campaigns here are amazing, or were amazing at least, and I am sure it will come back with time.
I don't think there's huge difference for running a casino in bear market or bull market because they're get profit based on coins equivalent, not USD equivalent. Unlike lending or staking sites where you lock your coins and get interest after leave for few months, bear market will affect their performance since they need to find a way to pay the interest.
I'd say bear market will make them get benefit since gamblers will try to gamble more in order to get profit from bear market and the fees is much lower due to the network aren't busy.