I think Barcelona will have a big advantage because they are playing at Camp Nou. They will play with courage because they are playing at their home ground. They will surely avenge their home defeat in this game. I am sure that Barcelona will win today, because if they lose this match they will be uncertain for the Champions League.
Deep analytics

But how did Barcelona get wiped out in the group stage last year then?
Most likely, Inter will play anti-Tiki-Taka: giving away ball control, covering all zones in their third of the field and counterattacks.
The result will depend on how Inter players are functionally ready to be extremely concentrated throughout the game. Well, maybe from individual actions, for example, Lewandowski. In general, I think Inter have an advantage.