from the H2H statistics of the matches between their meetings, Union Berlin was beaten three games by Dortmund with a fairly large score. next week, it looks like Union Berlin will be in trouble to beat Dortmund even though they play as hosts.
In my estimation, Dortmund will win this match.
Dortmund have always won their last 3 matches with a margin of more than 2 goals, so it is possible that this week will also end like that.
Union have performed well so far but with the condition of their squad now and the busy schedule they face this could be something difficult in my opinion because regardless of what if you look at Dortmund's condition from a player perspective it is clear they are better.