The 2022–23 UEFA Champions League group stage began on 6 September 2022 and will end on 2 November 2022. A total of 32 teams compete in the group stage to decide the 16 places in the knockout phase of the 2022–23 UEFA Champions League.

Eintracht Frankfurt made their debut appearance in the group stage (and first appearance in the European Cup since their loss in the 1960 final) after winning the 2021–22 UEFA Europa League and, as a result, this is the first time that five German clubs play in the group stage.

A total of 15 national associations are represented in the group stage. This season is the first since the 1995–96 season in which a Turkish side failed to qualify for the group stage. It is also the first time since the 2007–08 season that two Scottish sides qualified for the group stage.